Abstract
s / Biol Blood Marrow Transplant 19 (2013) S279eS312 S296 all patients are alive. At 18 months after transplantation, one patient experienced progressive pancytopenia, requiring red blood cell transfusion, in spite of the full donor chiemrism both in the bone marrow and peripheral blood T cells. Chimerism analysis of the peripheral blood T cells was analyzed later than 6 months post-transplant, showing mixed chimerism in 3 patients with stable hematopoiesis. The recovery of menstruationwas observed in all 4 evaluable young female patients at 3, 7, 8, and 9 months after transplantation, respectively. Conclusion: These results suggest that this regimen could be a safe and effective conditioning regimen of allogeneic HSCT for SAA both from sibling and unrelated donor. However, long-term follow-up is needed to further evaluate the dynamics of T-cell chimerism and the incidence of late-onset graft failure.
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