Abstract
Osteocytes are the most numerous cells in mature bone and have the potential to live as long as the organism itself. However, study and subsequent understanding of osteocyte biology has been thwarted by the remote location of the cell in the mineralized matrix. This review is intended to synthesize current understanding of osteocyte biology and to suggest future paths that will promote understanding of this obscure cell and translation of knowledge to disease prophylaxis and management. Cell facts • most abundant cells in mature bone; • average half-life of 25 years; • do not divide; • periosteocytic space provides largest surface area for ion exchange and molecular filtration in body.
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