The Ossabaw swine model of the Metabolic syndrome exhibit greater stenosis after coronary stenting than lean Yucatan swine.

Abstract

BACKGROUND Patients with the metabolic syndrome have poor prognosis after coronary stenting. Mechanisms underlying this pathology have been elusive because of the lack of a large animal model of the metabolic syndrome. HYPOTHESIS Lean Ossabaw swine predisposed to the metabolic syndrome (n=8; insulin-resistant, propensity to obesity) will exhibit greater in-stent stenosis after coronary stenting vs. lean Yucatan (n=4) swine. METHODS Bare metal stents were placed with 1x apposition (not over-inflation injury) verified by intravascular ultrasound (IVUS). Stenosis was evaluated using IVUS and histology 3–4 weeks later. Stenosis was calculated from the cross sectional neointimal area as a percent of the area within the internal elastic lamina in the stented segment. RESULTS Mean percent stenosis in Ossabaw was greater than Yucatan by IVUS (26±7% vs. 7±3%) and histological analysis (67±8% vs. 34±7%). These data suggest that the risk for increased stenosis already exists in lean Ossabaw pigs with insulin resistance and predisposed to obesity. CONCLUSIONS Ossabaw miniature swine are a novel humanoid model of the metabolic syndrome uniquely suited for the study of coronary interventional devices and mechanisms of accelerated restenosis. Support: NIH RR13223, HL62552, American Diabetes Association.