Abstract
A procedure for assessment of the effects of o-substituents in physical-organic systems by means of linear combination of substituent parameters is described and its applicability to various data sets on reactivity and equilibrium is shown. The procedure seems to provide a physicochemical background to the quantitative analysis of structure—activity relationships for biologically active aromatic ortho compounds. The ortho effect in biological activity is analyzed in terms of a linear combination of the electronic parameter σ p and field-inductive F, hydrophobic π and steric E s parameters. Depending on the type of steric effect, other parameters may be used. The model is shown to be applicable to several biological activity data sets of aromatic pesticide congeners including o-substituted derivatives.
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