Abstract
The functional building blocks of the brain are the neurons forming specialized neural networks which interact each other...
Highlights
The functional building blocks of the brain are the neurons forming specialized neural networks which interact each other and with the body periphery by the means of specialized loci where information is transferred: the synapses
The mechanism of synaptic transmission is simple in principle, it is finely regulated at different levels and the information content manipulated by important mechanisms of control
The repolarizing contribution given by the GABAA inhibitory synapse contribute less to the open of the NMDA but significantly increases the amplitude of the Excitatory Post Synaptic Potential (EPSP). The interplay of these mechanisms plays a very important role in shaping the EPSP and in regulating the Long Term Potentiation (LTP) and Long Term Depression (LTD) [42] indicating that these phenomena, if recorded in single synapses, probably depend mostly on the cooperativity among many synapses than on the single synapse activity [42]
Summary
The Origins of Variability in The Responses of The Glutamatergic Synapse. Biomed J Sci & Tech Res 23(4)-2019.
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