Abstract
1. The blood monocyte is a myeloid cell. 2. Blood monocytes originate in the bone marrow from promyelocytes. 3. The transformation of RES cells to blood monocytes hitherto has remained unproven and does not seem to be correct. 4. One of the most important functions of the blood monocytes is their macrophage-forming capacity after migration from the blood vessels. 5. There is no conclusive evidence for the existence of true histiocytes. However, the possibility remains that some such cells exist. Certainly their importance is negligible. 6. Many of these results indicate, that there is a macrophage system in the organism, in which the blood monocyte plays a primary and central part. The arrow obviously does not point from the RES to the blood and bone marrow cells: the reverse seems to be true.
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