Abstract
Retrograde tracing with the fluorescent dye, Fast Blue, was used to examine the origin and distribution of neurons whose axons project through the inferior mesenteric ganglion (IMG) of the guinea-pig. These studies were performed by applying the tracer to (a) the rostral cut-end of the hypogastric nerves and (b) the caudal cut-end of the intermesenteric nerve (IMN). After application of tracer to the hypogastric nerves retrogradely labelled cell profiles were observed in the IMG and the superior mesenteric ganglion (SMG). The number of labelled cell profiles in the SMG was consistently about 15% of the number in the IMG. In only one of seven animals tested were labelled cells seen in the wall of the colon. Application of tracer to the IMN labelled cells in the IMG and in the wall of the colon. The distribution of the labelled enteric neurons was skewed towards the anal end of the colon. These results confirm that postganglionic sympathetic neurons in the SMG project axons through the guinea-pig IMG and describe the colonic distribution of enteric neurons that project through the IMG and into the IMN.
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