Abstract
Publisher Summary This chapter discusses the organization and evolution of cloned globin genes. The genes responsible for the production of mouse hemoglobin are subject to at least two interesting and different forms of regulation. One form operates in trans and controls the expression of alpha and beta genes located on different chromosomes. The other operates in cis and regulates the expression of individual alpha or beta genes that are located close to one another on the same chromosome. The globin genes represent a complex set of sequences that are expressed in a coordinate fashion during the development of red blood cells. While this gene family can consist of as many as 10–14 members, three of these genes have been cloned and their entire nucleotide sequence has been determined. The globin system, both in mouse and other species, depends upon the development of recombinant DNA technology and rapid nucleotide sequencing techniques. Recombinant DNA technology provides a means of selecting a particular segment of the genome from among a million or so similar segments. This segment can then be amplified and made amenable to detailed structural studies and to genetic manipulation and assay.
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