Abstract
BackgroundTo elucidate the optimal number of prostate biopsy cores using a nomogram allocating 6–12 biopsy cores, the number generally used in daily practice, based on age and prostate volume (PV).MethodsWe enrolled 936 patients who received an initial prostate biopsy from April 2006 to January 2009. A number of 6–12 biopsy cores was allocated based on age and PV Nara Urological Research and Treatment Group (NURTG) nomogram. To elucidate the predictive parameters of cancer detection in patients with a prostate specific antigen (PSA) value in the gray zone, univariate and multivariate logistic regression analysis were carried out.ResultsThe total cancer detection rate and the cancer detection rate in the PSA gray zone (4.1–10.0 ng/mL) were 48.0 and 37.6 %, respectively. The cancer detection rates in the gray zone stratified by patient age of ≤59, 60–64, 65–69, 70–74, 75–79, and ≥80 years were 28.4, 35.0, 26.9, 37.9, 45.7, and 54.8 %, respectively. The significant predictive parameters of cancer detection in the gray zone were age, volume biopsy ratio (VBR: PV divided by number of biopsy cores), PSA density (PSAD), digital rectal examination findings, and transrectal ultrasound findings in univariate analyses. Finally, age, VBR, and PSAD were independent parameters to predict cancer detection in the gray zone. The adverse event profile was acceptable.ConclusionsOur present study revealed that the cancer detection rate using the NURTG nomogram allocating 6–12 biopsy cores, the number generally used in daily practice, based on age and PV, could provide similar efficacy as previous studies involving more biopsy cores. In older patients the number of biopsy cores could be reduced.
Highlights
To elucidate the optimal number of prostate biopsy cores using a nomogram allocating 6–12 biopsy cores, the number generally used in daily practice, based on age and prostate volume (PV)
To shed light on these issues, we conducted this prospective study to evaluate the NURTG (Nara Urological Research and Treatment Group: former Nara Urological Oncology Research Group: NUORG) nomogram allocating 6–12 biopsy cores, the number generally used in daily practice, based on age and PV
Nomogram allocating 6–12 biopsy cores, the number generally used in daily practice, based on age and PV
Summary
To elucidate the optimal number of prostate biopsy cores using a nomogram allocating 6–12 biopsy cores, the number generally used in daily practice, based on age and prostate volume (PV). Since the concept of systematic prostate biopsy has been introduced, the number of biopsy cores has increased to 12 cores. The number of cores gradually increased to improve the cancer detection rate. 10) cores based on the patients’ age and prostate volume (PV) They concluded that the cancer detection rate was 36.7 % in the gray zone of prostate specific antigen (PSA) (4.0–10.0 ng/mL) [2]. The concept of Remzi’s report to decide the number of cores based on age and PV is appropriate, because the meaning of the same number of cores for prostates of different volume is unscientific. We believe that the number of cores should be determined based on Tanaka et al BMC Res Notes (2015) 8:689
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