The optimal Magnesium Sulphate Dose for the Placenta as a Neuroprotection Organ

Abstract

Antenatal magnesium sulphate (Mg) is recommended for neuroprotection in cases of preterm birth before 32 weeks of gestation. Mg has been previously demonstrated to decrease fetal brain pro-inflammatory proteins level in response to stimuli. Despite Mg beneficial effects, recent evidence implies higher Mg doses may increase morbidity and mortality. The ACOG recommends using Mg in one of three protocols with a total level differences of seven-fold between the lowest to highest regimes. In the present study we sought to investigate the efficiency of different Mg levels to decrease pro-inflammatory placental reaction to LPS.