The Optimal Currency Hedging Policy with Biased Forward Rates

Abstract

<h3>Abstract</h3> Fatigue is prevalent in youth with perinatal stroke, but the causes are unclear. Predictive coding models of adult post-stroke fatigue suggest that fatigue arises from dysfunction in a sensorimotor prediction processing network. To date, the association between fatigue and sensorimotor network connectivity in youth with perinatal stroke has not been examined. The aim of the present study was to examine the association between fatigue and the function of the cortical sensorimotor prediction network in children with hemiparetic perinatal stroke. Resting-state functional magnetic resonance imaging was used to measure the functional connectivity between sensorimotor areas in youth with perinatal stroke. Self-reported fatigue was associated with stronger functional connectivity between the non-lesioned somatosensory cortex and the lesioned supplementary motor area. In contrast, fatigue was also associated with weaker functional connectivity between the lesioned and non-lesioned thalamus. In support of sensorimotor dysfunction models of post-stroke fatigue, these results indicate that fatigue in youth with hemiparetic perinatal stroke is associated with the functional connectivity of the sensorimotor prediction network. These results present potential cortical and behavioural targets for the treatment of fatigue in individuals with perinatal stroke.