Abstract
The aim of our study was to evaluate the effectiveness of various schemes of antihypertensive therapy in patients with chronic obstructive pulmonary disease and concomitant hypertension. Three different schemes of combined therapy with antihypertensive drugs have been assessed. It has been established that prolonged use of a combination of ACE inhibitors and beta –blockers caused a significant decrease in heart rate, in the number of episodes of painful and silent myocardial ischemia, ventricular extrasystoles of high grade. When combined, ACE inhibitor and diuretic decrease the value of the functional class of heart failure, the positive inotropic effect and the quality of life parameters improve significantly.A combination of ramipril and amlodipine had much better antyremodulating effect, and the pressure in the pulmonary arteries dropped. At the same time, all three therapies equally effectively reduced the level of office pressure.
Highlights
44 patients with essential hypertension have been examined in whose blood the indices of lipid peroxidation
It has been established that an activation of lipid peroxidation and decrease
of аntioxidant system occur in patients with essential hypertension
Summary
SPECIFIC CHARACTERISTICS OF LIPID PEROXIDATION AND АNTIOXIDANT SYSTEM IN PATIENTS WITH ESSENTIAL HYPERTENSION DEPENDING ON INSULINEMIA’S LEVEL
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