Abstract
Malignant tumors have been seriously threatening human’s life and health.Genetically engineered T cells can reprogram antigen specificity and functions.Chimeric antigen receptor (CAR)-T cells, also called as the CAR-T cells, is a kind of innovative adoptive therapy based on receptor synthesis.It carries specific antigen receptors and immunoregulatory co-stimulatory molecules independent of the major histocompatibility complex (MHC) to achieve efficient response to tumor targets.CAR-T cell therapy is effective in the treatment of hematological tumors, especially CD19-positive leukemia.However, this therapy still faces some obstacles in the treatment of solid malignant tumors.Targeted to overcome these problems, the development of new CAR-T cell therapy strategies for solid tumors is highly anticipated and has promising prospects. Key words: Chimeric antigen receptor T cells; Solid tumors; Adoptive T cell transfer
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