The O-polysaccharide of Escherichia coli O112ac has the same structure as that of Shigella dysenteriae type 2 but is devoid of O-acetylation: a revision of the S. dysenteriae type 2 O-polysaccharide structure

Andrei V Perepelov,Andrej Weintraub,Bin Liu,Sof’Ya N Senchenkova,Alexander S Shashkov,Lu Feng,Lei Wang,Göran Widmalm,Yuriy A Knirel

doi:10.1016/j.carres.2008.02.002

The O-polysaccharide of Escherichia coli O112ac has the same structure as that of Shigella dysenteriae type 2 but is devoid of O-acetylation: a revision of the S. dysenteriae type 2 O-polysaccharide structure

Andrei V Perepelov, Andrej Weintraub + Show 7 more

https://doi.org/10.1016/j.carres.2008.02.002

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Journal: Carbohydrate research	Publication Date: Feb 10, 2008
Citations: 14

Affiliation: N.D. Zelinsky Institute of Organic Chemistry, Karolinska University Hospital, Nankai University, Stockholm University

#Pyruvic Acid Acetal #Dysenteriae Type + Show 8 more

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Abstract

The O-antigen structure of Shigella dysenteriae type 2 was reinvestigated using chemical modifications along with high-resolution 2D 1H and 13C NMR spectroscopy. The O-antigen was found to contain a pyruvic acid acetal, which was overlooked in an early study, and the following revised structure of the pentasaccharide repeating unit was established: [Display omitted] where ∼70% GlcNAc residues bear an O-acetyl group at position 3. The O-antigen of Escherichia coli O112ac was found to have the same carbohydrate structure but to lack O-acetylation.

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