Abstract
The antinociceptive and anti-inflammatory activity of the opioid agonist TQ-1015 were evaluated in the carrageenan-induced model of mechanical allodynia and thermal hyperalgesia. Sixty male Sprague-Dawley rats were randomly allocated to one of 4 encoded doses of TQ-1015 or vehicle control. Inflammation of the left hindpaw was produced by SC injection of 0.05 ml of a 0.6% suspension of carrageenan. After 2.5 hours, the rats received TQ-1015 (0.3, 0.6, 1.2 or 1.5 mg/kg) or vehicle control. Paw withdrawal thresholds to light touch (von Frey filaments) and to noxious radiant heat (infrared), and paw volumes, were each determined prior to carrageenan, at 30, 45 and 60 minutes after drug injection (von Frey) and at 40, 55 and 70 minutes after injection (infrared, paw volume).
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