Abstract

The COVID-19 pandemic remains unrelenting as the autumn of 2020 approaches. Despite many clinical trials underway to find effective treatments for COVID-19, few studies have yielded positive results. Increasing evidence shows diffuse activation of the complement pathway in severe COVID-19 infections, from increased serum levels to widespread deposition in autopsy specimens.1–4 Initial case reports and case series using complement inhibitors in COVID-19 have shown promising results.5–8 The complement pathway, a key effector of the innate immune system, has emerged as a nidus of investigation in this pandemic.

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