Abstract
Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is a need to develop reliable approaches to their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments of cognition as well as language, speech, gait, retinal imaging, and eye tracking. Disorders studied include Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, and vascular cognitive impairment. Data from ONDRI will be collected into the Brain-CODE database to facilitate correlative analysis. ONDRI will provide a repertoire of endophenotyped individuals that will be a unique, publicly available resource.
Highlights
RÉSUMÉ: L’initiative de recherche sur les maladies neurodégénératives en Ontario
An initial volumetric analysis will be made by the imaging platform and the results provided to investigators
Ontario Neurodegenerative Disease Research Initiative (ONDRI) has already facilitated the development of standardized assessment protocols, which will allow for direct comparisons to be made across a range of neurodegenerative and neurovascular disorders
Summary
Six hundred participants who have one of the following diseases: AD/MCI (150: 75 AD; 75 MCI); ALS (90); FTD (60); PD (150); or VCI (150) will be enrolled into this longitudinal study from multiple centres throughout Ontario (Figure 1). Participants will perform three specific tasks including a pro-saccade and an anti-saccade task In the former, simple sensory motor function will be evaluated by the patient looking from a central fixation point to the target, eliciting a highly automatic response that is used to determine the shortest latency of visually triggered saccades and saccade metrics to assess the integrity of the visual and motor pathways. In the latter, the participant will be instructed to look away from the stimulus.
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