The Ontario Neurodegenerative Disease Research Initiative (ONDRI).

Sali M.k Farhan ,Lorne Zinman,Michael J Strong,David A Grimes,Robert Bartha,Douglas P Munoz,Dale Corbett,Richard H Swartz,Morris Freedman,Maria Carmela Tartaglia,Mario Masellis,Anthony E Lang,Elizabeth Finger,Robert A Hegele,Sandra E Black,Chris Hudson,William E Mcilroy,Sean Symons,Paula Mclaughlin ,Barry D Greenberg ,Peter Kleinstiver ,Stephen C Strother ,Manuel Montero‐Odasso ,Ondri Investigators ,David G Muñoz

doi:10.1017/cjn.2016.415

Abstract

Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is a need to develop reliable approaches to their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments of cognition as well as language, speech, gait, retinal imaging, and eye tracking. Disorders studied include Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, and vascular cognitive impairment. Data from ONDRI will be collected into the Brain-CODE database to facilitate correlative analysis. ONDRI will provide a repertoire of endophenotyped individuals that will be a unique, publicly available resource.

Highlights

RÉSUMÉ: L’initiative de recherche sur les maladies neurodégénératives en Ontario
An initial volumetric analysis will be made by the imaging platform and the results provided to investigators
Ontario Neurodegenerative Disease Research Initiative (ONDRI) has already facilitated the development of standardized assessment protocols, which will allow for direct comparisons to be made across a range of neurodegenerative and neurovascular disorders

Summary

Participants

Six hundred participants who have one of the following diseases: AD/MCI (150: 75 AD; 75 MCI); ALS (90); FTD (60); PD (150); or VCI (150) will be enrolled into this longitudinal study from multiple centres throughout Ontario (Figure 1). Participants will perform three specific tasks including a pro-saccade and an anti-saccade task In the former, simple sensory motor function will be evaluated by the patient looking from a central fixation point to the target, eliciting a highly automatic response that is used to determine the shortest latency of visually triggered saccades and saccade metrics to assess the integrity of the visual and motor pathways. In the latter, the participant will be instructed to look away from the stimulus.

SPECTRALIS SD-OCT segmentation validation

Findings

DISCUSSION