Abstract
1. 1. The various effects of delta-9 tetrahydrocannabinol (THC) in the eye are described, with a special emphasis on the ocular hypotensive action which is potentially useful in glaucoma. 2. 2. Critical analysis of the published reports reveals that the mechanism of action of THC is basically unknown. 3. 3. Although several studies indicate that the sympathetic system is involved in the ocular hypotensive action, the details are not understood. 4. 4. It is still debatable whether the THC effect in glaucoma is mainly central or principally due to a direct effect on the eye. This question must be answered in order to proceed logically to a better understanding of the mechanism involved and to the possible synthesis of THC derivatives which reduce intraocular pressure but do not have other actions.
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