Abstract
The comparison of proteins from a non-barophilous and a barophilous organism makes it possible to define the barophily ranks of amino acids. The correlation of these ranks with the number of codons attributed to amino acids in the genetic code, together with another straightforward argument based on an optimisation percentage of a barophily index (BI) (easily defined by barophily ranks) which can be associated to the genetic code table, suggest that the genetic code originated under high hydrostatic pressure. Moreover, as the BI value can be calculated for the sequence of any protein, it also makes it possible to define the BI for the genetic code if the number of codons attributed to the amino acids in the code is assumed to be the frequency with which the amino acids appeared in ancestral proteins. Finally, sampling the BI variable between many non-barophile organisms and from many proteins of a single non-barophile organism leads to the conclusion that the BI value of the genetic code is not typical of these organisms. Whereas, since the genetic code BI value is statistically higher than that of these non-barophile organisms, it supports the hypothesis that genetic code structuring took place under high hydrostatic pressure.
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