Abstract
Purpose: This retrospective observational study aimed to investigate the self-reported prevalence of seizure clusters (SCs) in patients with epilepsy (PWE) and its relationship with clinical characteristics.Methods: We retrospectively analyzed data from consecutive PWE from our hospital in northeastern China. Data were collected from the databank of a tertiary epilepsy center. Logistic regression models were employed to investigate the relationships between the individual patient demographic/clinical variables and the occurrence of SC.Results: In total, 606 consecutive PWE were included in the final analysis, and 268 (44.2%) patients experienced at least one seizure cluster. In multivariate logistic regression models, age (OR: 1.014; 95% CI: 1.002–1.027; p = 0.02), seizure frequency (OR: 2.08; 95% CI: 1.555–2.783; p < 0.001), multiple seizure types (OR: 5.111; 95% CI: 1.737–15.043; p = 0.003), number of current anti-seizure medications (ASM) (OR: 1.533; 95% CI: 1.15–2.042; p = 0.004), drug-resistant epilepsy (OR: 1.987; 95% CI: 1.159–3.407; p = 0.013), and a history of status epilepticus (OR: 1.903; 95% CI: 1.24–2.922; p = 0.003) were independent variables associated with a history of SC in PWE.Conclusion: Seizure clusters (SCs) are common occurrences at our study center. The occurrence of SC in individuals with epilepsy, to some extent, is determined by the epilepsy severity.
Highlights
Epilepsy is one of the most common serious brain disorders, affecting more than 70 million patients worldwide [1]
We retrospectively reviewed the medical records of patients in the databank from January 2020 to July 2021
In the multivariate logistic regression models, age (OR: 1.014; 95% CI: 1.002–1.027; p = 0.02), seizure frequency (OR: 2.08; 95% CI: 1.555–2.783; p < 0.001), multiple seizure type (OR: 5.111; 95% CI: 1.737–15.043; p = 0.003), number of present anti-seizure medication (ASM) (OR: 1.533; 95% CI: 1.15–2.042; p = 0.004), drug-resistant epilepsy (OR: 1.987; 95% CI: 1.159–3.407; p = 0.013), and history of status epilepticus (OR: 1.903; 95% CI: 1.24–2.922; p = 0.003) were independent variables associated with a history of Seizure clusters (SCs) in patients with epilepsy (PWE) for details
Summary
Epilepsy is one of the most common serious brain disorders, affecting more than 70 million patients worldwide [1]. 30% of patients with epilepsy (PWE) reported uncontrolled or poorly controlled seizures despite having appropriate anti-seizure medication (ASM) therapy [2]. SC is a common clinical phenomenon reported by many PWE [4,5,6,7]. One major reason for the varying prevalence of SC across the studies is the lack of a precise definition of SC [4, 10]. Different clinical definitions of SC have been applied previously, including ≥3 seizures within 24 h, >2 seizures within 24 h, and >2 seizures within 6 h [10]
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