The Occurrence of Genetic Recombination between Viruses and Human, it's Possible Influence on Vaccination

E P Kharchenko

doi:10.31631/2073-3046-2019-18-4-14

Abstract

Relevance. The genetic recombination between viruses and men is known long ago. It can be divided on relict and ontogenic ones. For the host the recombination may display different consequences the nature of which is not exposed explicitly.Aim is to analyze (on the base of computer comparison of the primary structure of viral and human proteins ) the occurrence of twodirectional recombination by small genome fragments between viruses and men and describe its possible after-effects.Materials and methods. For this computer study human and virus protein sequences were used from data bases available in INTERNET.Results. It was indicated that recombination (cryptical and explicit) by small genome fragments between viruses and men occurred many times in the past and many viruses pathogenic for men were involved in it.Conclusion. The bioinformatics approach allows to look at the past of viruses and men and find the traces of genetic information changes between them that may predetermine the effects of vaccines and diagnostic immune tests.

Highlights

For this computer study human and virus protein sequences were used from data bases available in INTERNET
It was indicated that recombination by small genome fragments between viruses and men occurred many times in the past and many viruses pathogenic for men were involved in it
The bioinformatics approach allows to look at the past of viruses and men and find the traces of genetic information changes between them that may predetermine the effects of vaccines and diagnostic immune tests

Summary

Introduction

Гомологичные фрагменты белков человека и вирусов Table 1.The homologous fragments of human and virus proteins Среди вирусов со множественной гомологией с белками человека – вирусы ТОРС (ВТОРС), Эбола, паротита, кори и особенно краснухи, простого герпеса, ЭпштейнаБарр.

Results

Conclusion