Abstract
AbstractFive Salmonella proteins, hitherto regarded as antigenically distinct, have been shown to share common antigenic determinants. It is proposed that the flagellar (H) antigens be designated as either Hv (variable) or Hc (common); in these terms the Kauffmann‐White schema describes the Hv determinants only. Antibodies to Hc determinants could be demonstrated by precipitation reactions detected by the Ouchterlony gel diffusion technique and by passive hemagglutination assays.To account for the finding that antibody to Hc determinants is not detected by bacterial immobilization assays it was proposed that Hv determinants are distributed along the flagella so that antibody can bind with two sites on the one flagella, thus disrupting the wave motion; in contrast, antibody to Hc determinants can only bind to one flagella at a time and therefore acts as a crosslink and does not cause immobilization.
Published Version
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