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Abstract
Electron microscopic studies of subcutaneous carrageenin granulomas induced in three different animal species revealed, in addition to several other ultrastructural changes in extracellular collagen fibers, the constant presence of normal SLS crystallites. This form of aggregation of tropocollagen molecules was observed throughout the entire evolution of the granuloma and is probably due to conditions created by the carrageenin in the tissue. It is suggested that SLS crystallites represent precipitation of intact tropocollagen monomers solubilized from previously constituted extracellular fibers, rather than aggregation of recently synthetized mononiers or precursors.The presence of SLS crystallites in one model of connective tissue degradation suggests that solubilization of established extracellular collagen fibers may be a regular feature of the general mechanism of collagen resorption.
Published Version
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