Abstract
Objective To investigate obstetric outcomes of multiparous pregnancies with advanced maternal age in different inter-pregnancy intervals. Methods A retrospective study was performed in 222 multiparous pregnancies with advanced maternal age from January 1st 2016 to December 31st 2016. According to the inter-pregnancy intervals, all cases were divided into four groups: Group A (1-3 years), group B (4-6 years) group C (7-9 years) and group D (≥10 years). The clinical characteristics, complications during pregnancy, maternal and fetal outcomes and duration of labor were compared and analyzed in the four groups. Results The average age of groups was significantly different (P<0.001). But there was no significant difference in the rate of oxytocin (P=0.465), incidence of gestational diabetes mellitus(P=0.698), pregnancy-induced hypertension (P=0.158), premature rupture of membrane (P=0.542) and postpartum hermorrhege (P=0.124) among the four groups. A total of 212 pregnancies underwent vaginal delivery. In group A, the first stage of labor last (239.16±137.63)min, which was significantly shorted than that in group B [(296.36±124.56)min], group C [(332.81±181.01)min]and group D [(337.19±224.02)min, P=0.030]. However, the interval of delivery did not prolong the second (P=0.137) and third stage of labor (P=0.079). The neonatal birth weight (P=0.276) and the neonatal sex (P=0.918), as well as admission of neonatal intensive care unit (NICU, P=0.103), were similar among three groups. The rate of neonatal asphyxia in group A and group D was higher than that in group B and group C (P=0.021). Conclusions Although the second and third stage were similar among multiparous pregnancies with advanced maternal age, the first stage of labor last longer in the longer inter-pregnancy interval. Furthermore, the risk of neonatal asphyxia was higher in women with inter-pregnancy interval ≤ 3 years or ≥ 10 years. Key words: Birth intervals; Parity; Maternal age; Pregnancy outcome
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