Abstract
chronic heart failure due to coronary arteria disease and activating the implanted ICD the therapy with amiodarone was doubled to 400mg/day. In the next week the patient developed a progressive weakness with inability to walk and to climb stairs. He admitted to the department of cardiology, where a rhadomyolysis was diagnosed.Maximumof creatinine kinasewas10.138U/L andmyoglobin 7.405ug/L. Parameters of infection and immune response were negative. Drug history revealed no use of thyroid drugs or statins, but the long-term use of bisoprolol, enalapril, torasemide and aspirin without any change prior to the occurrence of rhabdomyolysis. After 4weeks of in-patient rehabilitation the patient was discharged home without any ADL independence. An ambulatory training program was recommended. Conclusion.– Pubmed research and discussion with the manufacturer of amiodarone arise no association with the drugs used for heart failure therapy, so it seems possible that the rhabdomyolysis in this case is dose dependent.
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