Abstract
The clone composition of mouse bone marrow restored by transplantations of different doses of hemopoietic cells containing the unique genetic markers at the expense of integration of human adenosine deaminase gene is analyzed. Low dose of donor hemopoietic cells accelerates reversion of hemopoiesis to the recipient type and decreases the number of functioning clones. This finding confirms that a stem hemopoietic cell cannot maintain itself and its proliferative potential is limited. For long and stable repopulation of the recipient subjected to gene therapy, the maximum possible number of transduced stem hemopoietic cells should be transplanted.
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