Abstract
The method of retrograde axonal transport of horseradish peroxidase (HRP) was used to identify the motoneurons that innervate the soleus muscle in normal and dystrophic (C57BL/6J dy 2J/dy 2J) mice. In both normal and dystrophic animals the soleus motor nucleus was located in spinal segments L3 and L4, in a medial position in the lateral division of lamina IX. Measurements of the motoneuron soma area of HRP-labeled cells in normal and dystrophic animals showed that motoneuron size was bimodally distributed in both cases but that mean soma areas of motoneurons of both the large and small cell component from the dystrophic animals were larger. The number of alpha motoneurons was reduced in the dystrophic animals compared with the normal animals, the mean number of alpha motoneurons being 20 in the case of dystrophic animals and 25 in the case of normal animals.
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