Abstract
Null lymphocytes were defined as lymphocytes without detectable T- or B-cell markers using a battery of techniques. The null cell compartment was divided into pre-T cells, pre-B cells, and other null cells based upon their acquisition of membrane markers when incubated with ubiquitin. The null cell subpopulations were remarkably consistent in spleen cell suspensions from young adult mice of various strains. Commitment to T- or B-cell differentiation took place at the null cell stage and did not require thymic input. Pre-T cells, but not pre-B cells, were steroid sensitive. Pre-T cells accumulate with congenital thymic deficiency. This differed from senescent thymodeprivation where the outstanding finding was an accumulation of uninducible null cells. Neonatal mouse spleens were deficient in pre-T and pre-B cells but had an accumulation of uninducible cells.
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