Abstract
The present experiments were undertaken to determine whether or not behavioural effects in cats elicited by unilateral, reversible lesions in the nucleus linearis intermedius raphe modulate behavioural effects elicited by local application of dopamine into the caput nuclei caudati rostromedialis or by systemic injections of apomorphine. The data reported here suggest that the nucleus linearis is an indispensable link in the chain of intracaudate events triggered by direct or indirect activation of dopamine-sensitive sites within the caudate nucleus and strengthen the hypothesis that there exists a trans-synaptic relationship between nigro-caudate, dopaminergic and raphe-caudate, serotonergic fibres. The implication of these data is discussed with reference to the usefulness of a number of presently accepted test models in psychopharmacological research.
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