Abstract
The ribonucleic acid in the mitochondria, submicroscopic particles, supernatant, and purified nucleic of both resting and regenerating rat liver has been analyzed for its constituent purine and pyrimidine components without prior isolation of the nucleic acid. All of the fractions show essentially the same ratio of guanine to adenine, uridylic acid to cytidylic acid, and pyrimidine to purine, except for a significantly higher uridylic acid ratio in purified nuclei. Phosphorus analyses show that all the RNA phosphorus has been accounted for in the form of purine or pyrimidine bases, with the ratios of analytical RNA phosphorus to calculated pyrimidine plus purine phosphorus averaging about 0.90. This suggests that the intact ribonucleic acid macromolecule has more than one mole of base per mole of phosphorus. The significance of these results is discussed.
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