Abstract
Viruses of the Paramyxoviridae family share a common and complex molecular machinery for transcribing and replicating their genomes. Their non-segmented, negative-strand RNA genome is encased in a tight homopolymer of viral nucleoproteins (N). This ribonucleoprotein complex, termed a nucleocapsid, is the template of the viral polymerase complex made of the large protein (L) and its co-factor, the phosphoprotein (P). This review summarizes the current knowledge on several aspects of paramyxovirus transcription and replication, including structural and functional data on (1) the architecture of the nucleocapsid (structure of the nucleoprotein, interprotomer contacts, interaction with RNA, and organization of the disordered C-terminal tail of N), (2) the encapsidation of the genomic RNAs (structure of the nucleoprotein in complex with its chaperon P and kinetics of RNA encapsidation in vitro), and (3) the use of the nucleocapsid as a template for the polymerase complex (release of the encased RNA and interaction network allowing the progress of the polymerase complex). Finally, this review presents models of paramyxovirus transcription and replication.
Highlights
Members of the Paramyxoviridae family are enveloped viruses with non-segmented negative-strand RNA genomes
Paramyxoviruses are found in a broad range of animals, including mammals, fishes, reptiles, or birds and include several human and animal pathogens such as measles virus (MeV), mumps virus (MuV), canine distemper virus (CDV), and Newcastle disease virus (NDV)
Nipah virus (NiV), and is made of two helical turns interacting in a back-to-back manner (Figure in nucleocapsids extracted from NDV and Sendai virus (SeV) virions, suggests it may be biologically 3D)
Summary
Members of the Paramyxoviridae family are enveloped viruses with non-segmented negative-strand RNA genomes. RNA structures, well the made folding the use of the nucleocapsid a template, especially onhelps the complex interaction network nomic into secondaryas structures, which to prevent recognition byatinnate play between the nucleoprotein and the phosphoprotein. This review summarizes both immune receptors [11,12]. Viruses 2021, 13, 2465 been made on the use of the nucleocapsid as a template, especially on the complex interaction network at play between the nucleoprotein and the phosphoprotein This review summarizes both structural and functional insights on the nucleocapsid of paramyx of 28 oviruses, its assembly, and its role as a template.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
