Abstract
1. (1) The incorporation of 14C-formate into the nucleic acid bases of a variety of rapidly-growing avian and mammalian tissues has been studied in vivo and in vitro. 2. (2) In vivo the tissues studied incorporate 14C-formate extensively into their nucleic acid purines and DNA thymine. In vitro in most of the tissues studied, and particularly in the Ehrlich ascites tumour of the mouse, incorporation into nucleic acid purines is depressed although incorporation into DNA thymine remains high. However, in chick embryo liver and rat liver regenerating after partial hepatectomy, the pattern of incorporation in vivo is the same as in vitro. 3. (3) In the Ehrlich ascites carcinoma in vitro incorporation into nucleic acid purines is greatly increased by addition of 5-amino-4-imidazole carboxamide and its riboside or of a particle-free extract of mouse liver. Addition of glycinamide ribotide or riboside has no effect. 4. (4) The significance of these results is discussed.
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