Abstract
Summary The structure and protein composition of nuclear particles from rat liver were compared to that of rat brain previously described. Many similarities were found. (1) The liver particles were made of units (30–50 S monoparticles α and β, complexes heterogeneous in size, up to 200 S) with the same characteristics as described previously for brain [12]. (2) The overall protein compositions of the particles were similar and most of the major proteins were common to the two tissues. (3) The amount of a few proteins varied with the sedimentation coefficient of the particles in both tissues. The results suggest that the major particle proteins play a general role in the processing of premessenger RNA. However, the particles were not identical. The major difference lay in the quantitative distribution of the common proteins, suggesting that the composition of the constitutive units could vary, perhaps in relation with regulatory processes.
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