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Abstract
Tumor angiogenesis has been demonstrated to have an important role in the development, progression, and metastasis of pancreas cancer. Adrenomedullin-2 (ADM2) is a calcitonin gene-related peptide (CGRP) that has recently been shown to be a novel tumor angiogenesis factor, acting via ERK, Akt, and VEGF/VEGF-2 signaling pathways. Through the use of tissue microarray (TMA) technology, we hypothesize that ADM2 is an important tumor angiogenesis factor in pancreatic cancer.
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