Abstract
The not-so-infinite malleability of RNA viruses: Viral and cellular determinants of RNA virus mutation rates.
Highlights
Mutable, infinitely malleable, and all-powerful: this is often the underlying assumption for how spontaneous mutations fuel RNA virus adaptation
Without the capacity to detect and repair mismatched or damaged nucleotides, viral RNA genomes are prone to mutations introduced by mechanisms intrinsic and extrinsic to viral replication
It aims to provide an introduction to some of the mechanisms by which mutations arise during RNA virus replication, as viral mutation rates are the ultimate source of genetic diversity
Summary
Citation: Smith EC (2017) The not-so-infinite malleability of RNA viruses: Viral and cellular determinants of RNA virus mutation rates. PLoS Pathog 13(4): e1006254. https://doi.org/10.1371/ journal.ppat.1006254 Funding: This article was supported by start-up funds provided by Sewanee: The University of the South. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The author has declared that no competing interests exist.
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