Abstract
Stereotyped behavior produced by d-amphetamine (0, 5, 10 mg/kg) in male Holtzman rats with electrolytic lesions of the corpus striatum was compared with that produced in striatal sham operates and normal controls. While ratings of behavior over three test sessions demonstrated a highly significant drug dose effect (p <.001), amphetamine-induced stereotypy in the striatal lesion group did not differ significantly from that observed in the other two groups. These findings were discussed in reference to the importance of degree of striatal damage, time after surgery, and the proposed role of other dopaminergic sites to the mediation of the drug’s effect. The need for a critical examination of all experimental contingencies surrounding the proposed mediational role of the striatum is also stressed.
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