Abstract
The effect of the non-competitive NMDA receptor antagonist eliprodil on NMDA receptor- and voltage-operated Ca 2+ currents was investigated in rat cultured cortical neurons by using the whole-cell patch clamp technique. With neurons voltage-clamped at −40 mV, eliprodil reduced in concentration-dependent manner the inward current induced by N- methyl- D-aspartate (NMDA) (10 μM) in the presence of D-serine with an IC 50 of 0.67 μM ( I max=83%). Eliprodil also blocked the total inward Ba 2+ current carried in part by L- and N-type Ca 2+ channels with an IC 50 of 1.48 μM ( I max=87%). These results suggest that the neuroprotective properties of eliprodil could be due to its combined ability to antagonize the NMDA receptor- and voltage-operated Ca 2+ channels.
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