Abstract
The nitroxyl anion (HNO) donor, Angeli's salt, does not develop tolerance in vivo
Highlights
3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
Given we have shown previously that, unlike the NO donor glyceryl trinitrate (GTN), the HNO donor Angeli's salt (AS) does not develop tolerance in vitro [1], this study aimed to determine whether AS was resistant to the development of tolerance in vivo
Initial experiments using WKY rats confirmed that infusion with the HNO scavenger, N-Acetyl-Lcysteine (6.7 μmol/kg/min) significantly (P < 0.0001) attenuated the concentration dependent depressor responses to AS, whilst those to GTN or the additional NO donor, DEA/NO, were unchanged
Summary
3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. .
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