Abstract
The Karius test is a commercially available metagenomic next-generation sequencing test that can identify cell-free microbial DNA from over 1,200 pathogens. Although study designs have varied to date and its exact clinical role remains to be defined, in certain clinical scenarios, the assay may offer higher sensitivity for pathogen detection than conventional diagnostics, while avoiding the need for invasive sample collection procedures. Depending on the pathogen, the Karius test may allow faster identification, enabling earlier diagnosis and more targeted antimicrobial therapy. With this highly sensitive test comes the potential for polymicrobial results or reporting of possible commensal organisms. This limitation requires careful clinical interpretation within the context of each patient. Future research will hopefully better define the optimal patient population and timing, and the role of this assay in conjunction with conventional testing.
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