Abstract
G A A b st ra ct s the chronic colitis model, IL-4-/mice tended to have lower weight gain than WT mice, but this was not different significantly. In addition, both IL-4-/and WT mice had similar DAI, colon length and histologic severity of colitis on the end point. The expression of TNFα and MIP-2, and levels of MPO in colonic tissue also did not show significant difference between two groups. Conclusions: Our results suggest that IL-4 is not an important independent factor on regulation of acute and chronic DSS colitis.
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