Abstract
BackgroundThe aim of the study was to assess the value of pretreatment neutrophil/lymphocyte (N/L) ratio and mean platelet volume (MPV) and the correlation between these markers with progression in patients with severe odontogenic infection.Material and MethodsA cohort of 100 patients with severe odontogenic infection were divided into 2 groups according to their length of hospital stay. The N/L ratio and MPV was measured in all patients. The correlation in all patients between preoperative fever, preoperative antibiotic doses, postoperative antibiotic doses, total antibiotic doses and hospital stay with N/L ratio and MPV were analyzed. The Youden index was used to identify the optimal cut-off value.ResultsThere were positive and statistically significant correlations between N/L ratio and prolonged hospital stay and postoperative antibiotic doses and total antibiotic doses. The optimum cut –off level of N/L ratio was 5.19 according to ROC analysis. However, there was no correlation between MPV and any of these parameters.ConclusionsN/L ratio may be used as a prognostic marker for patients with odontogenic infections. These patients may need a higher dose of antibiotics and stay more than 1 day in hospital for the treatment of odontogenic infection when the N/L ratio is detected to be more than 5.19. Key words:Neutrophil/lymphocyte ratio, mean platelet volume, odontogenic infection.
Highlights
Patients with odontogenic infections need to be monitored because of the high risk for lethal complications due to the anatomical connectivity of potential spaces
Forty four patients were included in group 1 and 49 patient were in group 2 according to hospital stay
The most important finding of our study was that the N/L ratio was associated with hospital stay and antibiotic doses in patients with odontogenic infection
Summary
Patients with odontogenic infections need to be monitored because of the high risk for lethal complications due to the anatomical connectivity of potential spaces. Elevated high sensitivity Creactive protein (hs-CRP) and erythrocyte sedimentation rate (ESR) have been widely used as markers of inflammatory reactions in order to estimate the presence and severity of diseases Platelets, as another part of the natural immune system, can be elevated in response to “acute phase reaction” during the inflammation process. The aim of this study was to assess the value of pretreatment N/L ratio and MPV and the relation between these markers with prognostic factors such as the length of hospital stay, antibiotic doses in terms of recovery time and disease progression in patients with severe dental infection. The aim of the study was to assess the value of pretreatment neutrophil/lymphocyte (N/L) ratio and mean platelet volume (MPV) and the correlation between these markers with progression in patients with severe odontogenic infection. These patients may need a higher dose of antibiotics and stay more than 1 day in hospital for the treatment of odontogenic infection when the N/L ratio is detected to be more than 5.19
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