Abstract
We tested the neuroprotective effect of a novel, high affinity serotonin (5-HT 1A) agonist, BAY X3702, in a rat model of acute subdural hematoma (ASDH). Animals were treated with 0.01 mg/kg ( n=8), 0.003 mg/kg ( n=8) BAY X3702 or vehicle ( n=4) 15 min before (i.v.) and after (continuous infusion) injection of 400 μl of autologous blood into the subdural space. The ischemic brain damage at 4 h after ASDH was 59.01±39 and 60.8±49 mm 3 for the low- and high-dose BAY X3702 group, respectively, which was significantly smaller compared to the vehicle-treated ASDH group (106.2±33 mm 3). The result indicates that this novel, high affinity 5-HT 1A agonist, BAY X3702, is neuroprotective in this model.
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