Abstract
We assessed the possible influence of a neuropeptide FF analogue, 1DMe ([ d-Tyr 1,(NMe)Phe 3]neuropeptide FF), on the inhibitory action of endogenous and exogenous ∂-opioid receptor agonists on K +-evoked [Met 5]-enkephalin release from superfused rat spinal cord slices. 1DMe (0.1–10 μM) dose-dependently enhanced the increase in superfusate [Met 5]-enkephalin content due to the peptidase inhibitors thiorphan (1 μM) and bestatin (20 μM), and prevented the reduction in [Met 5]-enkephalin release due to stimulation of ∂ receptors by 1 μM deltorphin I. Because it had the same effects as ∂-opioid receptor antagonists, 1DMe might act through the functional blockade of presynaptically located ∂-opioid autoreceptors.
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