Abstract
Background The favoured animal model of cerebral malaria is an artificial host-parasite combination caused by Plasmodium berghei in inbred mouse strains [1]. Canine babesiosis caused by natural infection in dogs with Babesia rossi causes cerebral disease in some cases [2]. This disease demonstrates both similarities and differences to human malarial and comparisons may be of value in elucidating the pathogenesis of this serious complication in both hosts [3].
Highlights
The favoured animal model of cerebral malaria is an artificial host-parasite combination caused by Plasmodium berghei in inbred mouse strains [1]
The endothelial injury, parasitized red cell packing and perivascular haemorrhage showed some similarities to the neuropathology of human CM
The large haemorrhagic infarctions and clinical presentation with almost 100% mortality of dogs presenting with cerebral babesiosis were key differences
Summary
The favoured animal model of cerebral malaria is an artificial host-parasite combination caused by Plasmodium berghei in inbred mouse strains [1]. Necrosis occurred early in the development of the lesions before neuronal and glial changes. Conclusions The endothelial injury, parasitized red cell packing and perivascular haemorrhage showed some similarities to the neuropathology of human CM.
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