Abstract
Background Patients with schizophrenia and chronic substance abusers often display deficits in working memory function linked to prefrontal cortical dysfunction. Cortical dopamine transmission strongly influences the efficiency of capacity-constrained prefrontal activity. A recent fMRI study showed that amphetamine modulates cortical processing in line with an inverted-U type dose-response function. Repeated intermittent exposure to amphetamine in primates has been shown to result in augmentation of the behavioural response elicited by the drug (eg: hyperlocomotion) known as sensitisation. Chronic treatment produces cognitive deficits similar to those observed in clinical populations and sensitisation is a well established animal model of behavioural and neurochemical aspects of schizophrenia. In this study we use fMRI to examine the behavioural consequences and neural correlates of working memory function in healthy volunteers displaying behavioural sensitisation.
Highlights
Open AccessOwen O'Daly*, Panayiota Michalopoulou, Gabrielle Samson, Cori Smee, Derek Tracy, Robin Murray and Sukhwinder Shergill
Patients with schizophrenia and chronic substance abusers often display deficits in working memory function linked to prefrontal cortical dysfunction
Chronic treatment produces cognitive deficits similar to those observed in clinical populations and sensitisation is a well established animal model of behavioural and neurochemical aspects of schizophrenia
Summary
Owen O'Daly*, Panayiota Michalopoulou, Gabrielle Samson, Cori Smee, Derek Tracy, Robin Murray and Sukhwinder Shergill. Address: The Institute of Psychiatry, London, UK * Corresponding author from International Society on Brain and Behaviour: 2nd International Congress on Brain and Behaviour Thessaloniki, Greece. Published: 28 February 2006 Annals of General Psychiatry 2006, 5(Suppl 1):S88 doi:10.1186/1744-859X-5-S1-S88. en/p1I7n4te4r-n8a5t9ioXn-a5l-S1o-cfiueltl.ypdofn">Bhrearine.Burional Congress on Brain and Behaviour Meeting abstracts – A single PDF containing all abstracts in this Supplement is available
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
