Abstract
In recent years, a high number of studies have demonstrated that neuropsychological functions are altered in multiple sclerosis (MS) patients with cerebellar lesions, mainly including attention, working memory and verbal fluency. Since the present literature is often elusive on this topic, we aim to provide a comprehensive report about the real impact of cerebellar damages (evaluated as volume, lesions or connectivity measures) on cognitive functions. In particular in this review, we report and discuss recent works from 2009 to 2015, which have demonstrated the key role of the cerebellum in cognitive impairment of MS patients.
Highlights
Multiple sclerosis (MS) is a common disease that affects the central nervous system (CNS), in which focal inflammation causes the degradation of myelin in the nerve fibers [1]
As said in the Introduction, multiple sclerosis (MS) affects both motor and cognitive functions, and several studies have shown that a link exists between cerebellar dysfunction and specific cognitive impairment in MS
We investigated the correlation between cerebellar abnormalities and cognitive impairment as measured by neurophysiological tests
Summary
Multiple sclerosis (MS) is a common disease that affects the central nervous system (CNS), in which focal inflammation causes the degradation of myelin in the nerve fibers [1]. Cognitive impairment is recognized as a core feature of the disease, with prevalence estimates ranging from 40% to 65% [2]. The main cognitive functions affected by this disorder. 2015, 16 are: memory, processing speed, executive functions, attention and concentration and visuospatial abilities [3]; whereas other cognitive domains—such as language, short-term memory and general intelligence—are generally preserved [4] Sci. 2015, 16 are: memory, processing speed, executive functions, attention and concentration and visuospatial abilities [3]; whereas other cognitive domains—such as language, short-term memory and general intelligence—are generally preserved [4]
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