The Neuro Patterns Prior to Error Responses in Long-Lasting Working Memory Task: An Event-Related Potential Study

Yi Xiao,Weicai Tang,Jintao Wu,Feng Ma,Chenhui Sun,Fenggang Xu,Shanguang Chen,Wenhao Zhan,Lizhi Wang,Jiaxuan Li,Huijong Yan,Yuan Yang

doi:10.3389/fnbeh.2019.00277

Abstract

Few studies exist regarding the mechanism prior to response by which cognitive impairment may induce error in a single long-lasting task. The present study intends to clarify the changes in cognition at the electrophysiological level. Changes in amplitude and latency of N1, P2, N2, and P3 components of event-related potentials (ERPs) were analyzed for error and correct trials during normal and fatigue. Twenty-nine participants had to perform a 2-back working memory (WM) task for 100 min. The first 10 min and the last 10 min of the task were used as the normal state and fatigue state of the participant, respectively. EEG data were obtained from the first 10-min period and the final 10-min period. The results revealed smaller P3 and P2 amplitudes and longer P2 and N2 latency in the final 10-min which was after a long-lasting time task. Moreover, smaller P3 and P2 amplitudes but larger N2 amplitudes were observed in error trials for both states. Our results indicated that: (1) long lasting involvement in a cognitive task had a detrimental effect on attention, memory updating and cognitive control; and (2) impaired attention, impairments in memory updating and cognitive control were related to task errors. Our results imply that several impaired cognitive processes were consistently associated with the error and the altered ERP represents the neural patterns prior to error response in mental fatigue state.

Highlights

Long-lasting engage in a cognitive task leads to impair attention, working memory (WM) and cognitive control
The results showed that mental fatigue led to negative affection on the participants
The results showed that mental fatigue led to more errors (b)

Summary

Introduction

Long-lasting engage in a cognitive task leads to impair attention, working memory (WM) and cognitive control. Some studies in older and patients found that increased N2 amplitude reflected an enhanced energetic cost in cognitive control (Bruder et al, 1998, 2001; Nieuwenhuis et al, 2005; Daurignac et al, 2006; Guillem et al, 2006; Folstein and Van Petten, 2008; Daffner et al, 2011b; O’Connell et al, 2012; Shu et al, 2014; Sumich et al, 2014; Pinal et al, 2015a; Zuj et al, 2017), suggesting that the patients used more resources for the response selection These results are consistent with the mental fatigue effect. The results showed that resource allocation was attenuated in mental fatigue for no-go stimuli

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