Abstract
Background and Objective:Modern neuroimaging has demonstrated that cognitive functions are based in networks of interconnected modules. The purpose of this paper was to analyze the connectivity of Brodmann's area (BA) 22 in lexico-semantic tasks. MethodsA connectivity fMRI co-activation study was performed by pooling data of lexico-semantic tasks in which BA22 (core of Wernicke's area) was reported. 283 subjects reported in 21 experiments were analyzed. Analysis of Likelihood Estimates of pooled data was utilized to generate the connectivity map; thresholds at p< 0.01 were corrected for multiple comparisons with false discovery rate. Resulting images were co-registered into MNI standard space.Results:network consisting of 13 clusters of activation was obtained. Main clusters were located in the left posterior temporal and left inferior frontal gyrus; in addition to these canonical areas, left insula, pre-supplementary motor area, left BA37, primary auditory areas and left occipital lobe were also involved. Conclusions: BA22-related networks involved in lexico-semantics processing were demonstrated utilizing a pooling-data connectivity study. Significance, interpretation and limitations of the results are discussed.
Highlights
The contribution of Brodmann's cortical parcelation to the understanding and description of brain functions has been of critical importance in the field of neuroscience
A connectivity fMRI co-activation study was performed by pooling data of lexico-semantic tasks in which BA22 was reported. 283 subjects reported in 21 experiments were analyzed
The main cluster corresponds to the left inferior frontal gyrus (BA44, BA45) and adjacent anterior insula (BA13), BA46 and BA47
Summary
The contribution of Brodmann's cortical parcelation to the understanding and description of brain functions has been of critical importance in the field of neuroscience. A large number of publications correlate brain function to networks; there is a paucity of articles examining the bases and theoretical background on this topic Despite this lack, it is currently well accepted that cognition correlates to brain network configuration [5]. It is currently well accepted that cognition correlates to brain network configuration [5] This means that any specific area (e.g., BA22) may connect with different modules, depending of the task, yielding specific network configurations from which arise distinct brain functions. Methods: A connectivity fMRI co-activation study was performed by pooling data of lexico-semantic tasks in which BA22 (core of Wernicke's area) was reported. Conclusions: BA22-related networks involved in lexico-semantics processing were demonstrated utilizing a pooling-data connectivity study.
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