Abstract
> The heart holds answers the brain refuses to see > > —Rob Kall The regenerative capability of the heart is clinically relevant, as is the inability of adult heart to replace the lost cardiomyocytes after cardiac injury contributes to the ongoing encumbrance of heart failure.1 However, compared with adult mammals, lower organisms can regenerate their hearts after an injury, including frogs, newts, and zebrafish.2–7 Remarkably, neonatal mice can also regenerate their hearts for ≤7 days after their birth.8,9 In this perspective, a thorough understanding of the regulatory mechanisms in the neonatal hearts will help to unravel the obstacles in reactivating the hidden regenerative capability of adult hearts. Article, see p 990 Several conserved mechanisms for cardiac regeneration have been put forward, such as cardiomyocyte proliferation,8,9 epicardial cell activation,10,11 monocyte/macrophages, and angiogenesis.12 Further understanding on other potential factors that trigger the adult mammalian cardiac regeneration is of a key scientific and therapeutic importance. Along these lines, the study by White et al in this issue of Circulation Research provides a new avenue on the role of sympathetic nerves for neonatal cardiac regeneration.13 For more than a century …
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
