Abstract
Objective To research the nerve protective effect of ciliary neurotrophic factor (CNTF) after cat optic nerve not entire injury.Methods Completes the cat optic nerve not entire damage model.The experimental group gives CNTF by in the vein,the anterior chambe,the intravitreal to inject separately,the control group gives the physiological saline.Operation latter 15 days of two-sided anterior colliculi,lateral geniculate body microinjection DiI retrogradation nerve tracing.The different time spot completes the examination of visual evoked potential (PVEP).Operation latter 30 days complete the situ heart dabbling;Retina stretched preparation,retina ganglion cell counting.Takes the optic nerve of operation side,the light microscope and the electron microscope observation morphologic change of optic nerve.Result Controlled group PVEP compares the experimental groups oscillation amplitude of P100 to decrease obviously,incubation period of P100 obvious extension,difference remarkable (P ＜ 0.0l ).Compares with the controlled group,the survival number of retina ganglion cell of experimental groups increases obviously(P＜0.01 ),the nerve structure is more complete.Conclusion After optic nerve not entire damage,the CNTF different way injection has the optic nerve protective effect,but effect existence difference. Key words: Ciliary neurotrophic factor; Optic nerve injury; Visual evoked potential; Retrogradation nerve trace
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